Explainers
Summaries of Important Topics in Science and Medicine
Niacin (Vitamin B3) Metabolism and Heart Disease
The GeneBank and CardioLipin studies measured niacin metabolism in a specialist referral setting. A niacin metabolite, 4PY, predicted future cardiac event risk. Mice exposed to synthetic 4PY showed elevated blood vessel inflammation.
This is a simplified look at a complex clinical trial. Full details are available at clinicaltrials.gov, the German Clinical Trials Register, and in the following publication:
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk | Nature Medicine
The GeneBank and CardioLipin studies measured niacin metabolism in a specialist referral setting. A niacin metabolite, 4PY, predicted future cardiac event risk. Mice exposed to synthetic 4PY showed elevated blood vessel inflammation.
This is a simplified look at a complex clinical trial. Full details are available at clinicaltrials.gov, the German Clinical Trials Register, and in the following publication:
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk | Nature Medicine
Red meat plus Gut Microbes equals Heart Disease (The APPROACH Trial):
The APPROACH trial tested in the community setting what already known in the laboratory setting: micro-organisms colonizing the colon mediate the relationship between red meat and cardiovascular disease.
This is a simplified look at a complex clinical trial. Full details are available at clinicaltrials.gov and in the following publications:
Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults | Journal of the American Heart Association (ahajournals.org)
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota l-carnitine catabolism | Nature Microbiology
The APPROACH trial tested in the community setting what already known in the laboratory setting: micro-organisms colonizing the colon mediate the relationship between red meat and cardiovascular disease.
This is a simplified look at a complex clinical trial. Full details are available at clinicaltrials.gov and in the following publications:
Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults | Journal of the American Heart Association (ahajournals.org)
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota l-carnitine catabolism | Nature Microbiology
My view of what science is and how it works in practice.
